Curaleaf Ground Flower Bulk Refills Sativa contain all-natural cannabis flower and cannabis plant terpenes for vaporization. Each refill contains 7g (1/4 oz) of premium cured cannabis and 1400mg of major cannabinoids. Inhalation is the fastest-acting route of administration. When inhaled, the active cannabinoids pass directly into the bloodstream from the lungs. One slow, controlled inhalation lasting two seconds delivers approximately 2.5mg of active cannabinoids. Effects occur in 90 seconds, lasting for two to three hours and for some patients up to 12 hours.